Current Issue : October - December Volume : 2020 Issue Number : 4 Articles : 5 Articles
Combination of chemotherapy and immunotherapy has been a promising strategy in cancer\ntreatment. Polysaccharides from Angelica sinensis (AP), a well-known Chinese herbal medicine,\nhave been proved to have good immunomodulatory activity. In the present study, an enzyme-sensitive\ntumor-targeting nano drug delivery system (AP-PP-DOX (doxorubicin), PP stood for peptide)\nwas constructed. In this system, Angelica polysaccharides act as not only carriers to targeted\ndelivery of drugs to tumor tissue but also eectors to improve tumor microenvironment and enhance\nimmune function, resulting in synergistic antitumor eect with chemotherapy drugs. The structure\nof this conjugate was confirmed by FI-IR and 1H-NMR. The particle size and zeta potential of\nthe nanoparticles were...................................................................................................
Augmented renal clearance (ARC) refers to the state of heightened renal filtration commonly\nobserved in the critically ill. Its prevalence in this patient population is a consequence of the bodyâ??s\nnatural response to serious disease, as well as the administration of fluids and pharmacologic therapies\nnecessary to maintain sufficient blood pressure. ARC is objectively defined as a creatinine clearance\nof more than 130 mL/min/1.73 m2 and is thus a crucial condition to consider when administering\nantibiotics, many of which are cleared renally. Using conventional dosing regimens risks the possibility\nof subtherapeutic concentrations or clinical failure. Over the past decade, research has been conducted\nin patients with ARC who received a number of antibacterials frequently used in the critically ill,\nsuch as piperacillin-tazobactam or vancomycin. Strategies to contend with this condition have also\nbeen explored, though further investigations remain necessary....
cyclic peptide containing one cysteine and five alternating tryptophan and arginine\namino acids [(WR)5C] was synthesized using Fmoc/tBu solid-phase methodology. The ability of the\nsynthesized cyclic peptide to produce gadolinium nanoparticles through an in situ one-pot mixing of\nan aqueous solution of GdCl3 with [(WR)5C] peptide solution was evaluated. Transmission electron\nmicroscopy showed the formed peptide-Gd nanoparticles in star-shape morphology with a size\nof ~250 nm. Flow cytometry investigation showed that the cellular uptake of a cell-impermeable\nfluorescence-labeled phosphopeptide (F0-GpYEEI, where F0 = fluorescein) was approximately six\ntimes higher in the presence of [(WR)5C]-Gd nanoparticles than those of F0-GpYEEI alone in human\nleukemia adenocarcinoma (CCRF-CEM) cells after 2 h incubation. The antiproliferative activities\nof cisplatin and carboplatin (5 microM) were increased in the presence of [(WR)5C]-GdNPs (50 microM) by\n41% and 18%, respectively, after 72-h incubation in CCRF-CEM cells. The intracellular release of\nepirubicin, an anticancer drug, from the complex showed that 15% and 60% of the drug was released\nintracellularly within 12 and 48 h, respectively. This report provides insight about using a non-toxic\nMRI agent, gadolinium nanoparticles, for the delivery of various types of molecular cargos....
Silk fibroin is a biocompatible, non-toxic, mechanically robust protein, and it is commonly\nused and studied as a material for biomedical applications. Silk fibroin also gained particular interest\nas a drug carrier vehicle, and numerous silk formats have been investigated for this purpose. Herein,\nwe have prepared electrospun nanofibers from pure silk fibroin and blended silk fibroin/casein,\nfollowed by the incorporation of an anti-inflammatory drug, diclofenac. Casein serves as an excipient\nin pharmaceutical products and has a positive eect on the gradual release of drugs. The characteristics\nof the investigated composites were estimated by scanning electron microscope, transmission electron\nmicroscope, thermogravimetric analysis, and a lifetime of diclofenac by electron paramagnetic\nresonance analysis. The cumulative release in vitro of diclofenac sodium salt, together with the\nantiproliferative eect of diclofenac sodium salt-loaded silk nanofibers against the growth of two\ncancer cell lines, are presented and discussed....
This work describes the development of a gastroresistant antimicrobial formulation\ncomposed of two carriers, pectin and liposomes, intended to improve the effciency of norfloxacin\n(NOR) against multi-resistant bacterial strains. The formulations showed physicochemical stability\nfor 180 days (4 C) in terms of size, polydispersity, and zeta potential of the vesicles, prolonging the\nin vitro release of NOR for 11 h. The hybrid nanocarriers improved the in vitro antimicrobial activity\nagainst different multidrug-resistant bacterial strains, such as Salmonella sp., Pseudomonas aeruginosa,\nE. coli and Campylobacter jejuni, in comparison to commercial NOR and liposomal suspensions.\nThe in vivo toxicity assay in chicken embryos revealed that the hybrid systems were not toxic in\nany of the different parameters analyzed, a result also corroborated by the analyses of biochemical\nbiomarkers of the chicken-embryos liver function....
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